Postal address

Uppsala universitet
Womens and childrens health
Akademiska sjukhuset
SE-751 85 Uppsala, Sweden

Clinical Psychology in Healthcare
Uppsala universitet
Uppsala biomedicinska centrum
Institutionen för kvinnors och barns hälsa
Klinisk psykologi i hälso- och sjukvård
Box 572
SE-751 23 Uppsala, Sweden

Visiting address

MTC-house: Dag Hammarskjölds väg 14B, 2 tr
Obst/Gyn, Pediatrics: Akademiska sjukhuset, Entr 95-96 lower ground
IMCH: Drottninggatan 4, 4th floor
Clinical Psychology in Healthcare: Husargatan 3, BMC, D11

Phone

+46 18 611 00 00 (exchange)

Fax

MTC-house: +46 18 611 55 83
IMCH: +46 18 50 80 13

E-mail

kbh@kbh.uu.se
forename.surname@kbh.uu.se

Gynecological endocrinology

Endogenous sex hormones are essential for reproductive function. Steroid hormones also affect connective tissue and muscle elements with effect on bone mass, skin and structure and function of the artery wall. Sex hormones also profoundly affect the brain function and tentatively can modify the aging process of the brain.

Bone mass and Fracture risk

We study effects of endogenous and exogenous sex hormones on bone mass and fracture risk. Menopausal hormone replacement (HRT) profoundly reduces fracture risk already soon after menopause. Our results indicate that HRT affects the brain, with improved postural balance function, which most likely can explain that HRT has a primary preventive effect to reduce forearm- and hip fracture risks, already soon after menopause.

Cardiovascular system, cardiovascular disease (CVD) and the brain

We study the effect of endogenous sex hormones in men and women and the effect of HRT in women on the artery wall layer dimensions, artery wall function and aging and relations to prevalent CVD and coming risk of CVD events. In addition, we study effect of long term estrogen therapy on total and relative brain volumes (esp. hippocampal region) and function of the aromatase system (local estrogen synthesis) in the brain. We evaluate non-invasive high-frequency ultrasound with regard to vascular risk in connection with SLE, pre-eclampsia. Recurrent depressions in young subjects and effects of anti-estrogen therapy in breast cancer patients and effects of long-term use of hormonal contraception. Technologies used include non-invasive high-frequency ultrasound (20 –50MHz) for artery wall imaging, MRI, positron-emission-tomography (PET) and liquid chromatography – tandem mass spectrometry (LC-MS/MS).

Premenstrual syndrome (PMDD or PMS)

The normal variations in sex steroids during the menstrual cycle give negative effect on mood and temper (irritability and depressed mood) in some women. We study differences in the brain sensitivity to changes in sex hormone levels in women with and without PMS. We also study the serotonin system with brain PET (11C-5HTP).

Polycystic Ovary Syndrome (PCOS)

In the ovarian follicular fluid (FF) from PCOS and healthy women, we study steroid hormone composition and the enzyme activities that synthesize androgens and estrogens to elucidate mechanisms behind PCOS. LC/MS/MS methods are used.

In vitro fertilization (IVF)

Content and pattern of steroid hormones/proteins in the ovarian follicular fluid surrounding each aspirated egg are related to outcome. We aim developing methods indicating which egg has better chance in implantation and to result in a born baby. LC/MS/MS methods are used.